Current Issue : April - June Volume : 2016 Issue Number : 2 Articles : 2 Articles
Multiparticulate drug delivery system have the several advantage in comparison to single unit dosage form like predictable, reproducible and short gastric residence time, less inter- and intra-subject variability, improve bioavailability, reduced adverse effects, improved tolerability, limited risk of local irritation and no risk of dose dumping. Salt form of carvedilol, such as carvedilol phosphate, with greater aqueous solubility, chemical stability etc., may offer potential benefits for provision of medicinal products containing the drug carvedilol, including the ability to achieve desired or prolonged systemic drug levels by sustaining absorption along the gastro-intestinal tract, particularly in regions of neutral pH where carvedilol has minimal solubility. There exists a need in the art for alternate ways to formulate compositions of carvedilol salts especially extended release compositions. Pulsatile is such a drug delivery system where drug is released of a sudden after well-defined time gap (lag time) according to circadian rhythm of disease states. The diseases recently targeted for pulsatile drug delivery include asthma, arthritis, duodenal ulcer, cancer, cardiovascular diseases, diabetes, hypercholesterolemia and neurological disorders etc. which have good circadian rhythm. In this invention, once daily chronotherapeutic triphasic pulsatile multiparticulate controlled release dosage form of carvedilol phosphate was prepared by combining immediate release (IR) pellets, delayed release (DR) pellets and controlled release (CR) pellets in suitable ratio to deliver carvedilol phosphate in appropriate manner matching circadian rhythm of humans to facilitate once daily administration. The above formulation was evaluated for chemical parameters like assay and in-vitro drug release study....
Nanogels are crosslinked polymeric particles, which can be considered as hydrogels if they are composed of water soluble or swellable polymer chains. Nanogels based materials have high drug loading capacity, flexibility, biocompatibility and biodegradability which are the key points to design a drug delivery system effectively. Nanogels are emerging drug carriers for the delivery of drugs. They possess unique advantages for polymer-based drug delivery systems (DDS). Based on the polymeric systems used, different stimuli-responsive nanogels, such as pH-responsive, temperature-sensitive, light sensitive and ion-sensitive systems can be prepared. This review describes the recent developments of nanogel particles as drug delivery carriers for biological and biomedical applications. Various synthetic method for the preparation of nanogels are detailed, it include photolithographic and micro-molding methods, continuous microfluidics, fabrication of biopolymers and heterogeneous free radical polymerizations....
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